Ontology highlight
ABSTRACT:
SUBMITTER: Agranat-Tamir L
PROVIDER: S-EPMC3985634 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Nucleic acids research 20140124 7
MicroRNAs (miRNAs) are central regulators of gene expression, and a large fraction of them are encoded in introns of RNA polymerase II transcripts. Thus, the biogenesis of intronic miRNAs by the microprocessor and the splicing of their host introns by the spliceosome require coordination between these processing events. This cross-talk is addressed here. We show that key microprocessor proteins Drosha and DGCR8 as well as pre-miRNAs cosediment with supraspliceosomes, where nuclear posttranscript ...[more]