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First report of KPC-2 Carbapenemase-producing Klebsiella pneumoniae in Japan.

ABSTRACT: We investigated a novel Japanese isolate of sequence type 11 (ST11), the Klebsiella pneumoniae carbapenemase-2 (KPC-2)-producing K. pneumoniae strain Kp3018, which was previously obtained from a patient treated at a Brazilian hospital. This strain was resistant to various antibiotic classes, including carbapenems, and harbored the gene blaKPC-2, which was present on the transferable plasmid of ca. 190 kb, in addition to the blaCTX-M-15 gene. Furthermore, the ca. 2.3-kb sequences (ISKpn8-blaKPC-2-ISKpn6-like), encompassing blaKPC-2, were found to be similar to those of K. pneumoniae strains from China.

SUBMITTER: Saito R

PROVIDER: S-EPMC3993235 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature

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First report of KPC-2 Carbapenemase-producing Klebsiella pneumoniae in Japan.

Saito Ryoichi R Takahashi Rieko R Sawabe Etsuko E Koyano Saho S Takahashi Yutaka Y Shima Mari M Ushizawa Hiroto H Fujie Toshihide T Tosaka Naoki N Kato Yuko Y Moriya Kyoji K Tohda Shuji S Tojo Naoko N Koike Ryuji R Kubota Tetsuo T

Antimicrobial agents and chemotherapy 20140224 5

We investigated a novel Japanese isolate of sequence type 11 (ST11), the Klebsiella pneumoniae carbapenemase-2 (KPC-2)-producing K. pneumoniae strain Kp3018, which was previously obtained from a patient treated at a Brazilian hospital. This strain was resistant to various antibiotic classes, including carbapenems, and harbored the gene blaKPC-2, which was present on the transferable plasmid of ca. 190 kb, in addition to the blaCTX-M-15 gene. Furthermore, the ca. 2.3-kb sequences (ISKpn8-blaKPC-2 ...[more]

PMID: 24566171

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