Ontology highlight
ABSTRACT:
SUBMITTER: Zhang H
PROVIDER: S-EPMC3347694 | biostudies-literature | 2012 Jun
REPOSITORIES: biostudies-literature
Zhang Hongjie H Kim Ahlee A Abraham Nessy N Khan Liakot A LA Hall David H DH Fleming John T JT Gobel Verena V
Development (Cambridge, England) 20120425 11
Clathrin coats vesicles in all eukaryotic cells and has a well-defined role in endocytosis, moving molecules away from the plasma membrane. Its function on routes towards the plasma membrane was only recently appreciated and is thought to be limited to basolateral transport. Here, an unbiased RNAi-based tubulogenesis screen identifies a role of clathrin (CHC-1) and its AP-1 adaptor in apical polarity during de novo lumenal membrane biogenesis in the C. elegans intestine. We show that CHC-1/AP-1- ...[more]