Ontology highlight
ABSTRACT:
SUBMITTER: Tata A
PROVIDER: S-EPMC4033773 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Tata Aleksandra A Stoppel David C DC Hong Shangyu S Ben-Zvi Ayal A Xie Tiao T Gu Chenghua C
The Journal of cell biology 20140519 4
Extracellular signals have to be precisely interpreted intracellularly and translated into diverse cellular behaviors often mediated by cytoskeletal changes. Semaphorins are one of the largest families of guidance cues and play a critical role in many systems. However, how different cell types translate extracellular semaphorin binding into intracellular signaling remains unclear. Here we developed and performed a novel image-based genome-wide functional RNAi screen for downstream signaling mole ...[more]