Ontology highlight
ABSTRACT:
SUBMITTER: Roulois D
PROVIDER: S-EPMC4843502 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Cell 20150801 5
DNA-demethylating agents have shown clinical anti-tumor efficacy via an unknown mechanism of action. Using a combination of experimental and bioinformatics analyses in colorectal cancer cells, we demonstrate that low-dose 5-AZA-CdR targets colorectal cancer-initiating cells (CICs) by inducing viral mimicry. This is associated with induction of dsRNAs derived at least in part from endogenous retroviral elements, activation of the MDA5/MAVS RNA recognition pathway, and downstream activation of IRF ...[more]