Ontology highlight
ABSTRACT:
SUBMITTER: Thacker BE
PROVIDER: S-EPMC4039620 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Thacker Bryan E BE Xu Ding D Lawrence Roger R Esko Jeffrey D JD
Matrix biology : journal of the International Society for Matrix Biology 20131219
Many protein ligands bind to heparan sulfate, which results in their presentation, protection, oligomerization or conformational activation. Binding depends on the pattern of sulfation and arrangement of uronic acid epimers along the chains. Sulfation at the C3 position of glucosamine is a relatively rare, yet biologically significant modification, initially described as a key determinant for binding and activation of antithrombin and later for infection by type I herpes simplex virus. In mammal ...[more]