Ontology highlight
ABSTRACT:
SUBMITTER: Simon MD
PROVIDER: S-EPMC4045704 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Chembiochem : a European journal of chemical biology 20140311 5
A flow-based solid-phase peptide synthesis methodology that enables the incorporation of an amino acid residue every 1.8 min under automatic control or every 3 min under manual control is described. This is accomplished by passing a stream of reagent through a heat exchanger into a low volume, low backpressure reaction vessel, and through a UV detector. These features enable continuous delivery of heated solvents and reagents to the solid support at high flow rate, thereby maintaining maximal co ...[more]