Ontology highlight
ABSTRACT:
SUBMITTER: Hussey KM
PROVIDER: S-EPMC4054320 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Hussey Kristine M KM Chen Hongshan H Yang Christine C Park Eugene E Hah Nasun N Erdjument-Bromage Hediye H Tempst Paul P Gamble Matthew J MJ Kraus W Lee WL
Molecular and cellular biology 20140421 13
MacroH2A1 is a histone variant harboring an ∼25-kDa carboxyl-terminal macrodomain. Due to its enrichment on the inactive X chromosome, macroH2A1 was thought to play a role in transcriptional repression. However, recent studies have shown that macroH2A1 occupies autosomal chromatin and regulates genes in a context-specific manner. The macrodomain may play a role in the modulation of gene expression outcomes via physical interactions with effector proteins, which may depend on the ability of the m ...[more]