Ontology highlight
ABSTRACT:
SUBMITTER: Strotmeier J
PROVIDER: S-EPMC4067265 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Strotmeier Jasmin J Mahrhold Stefan S Krez Nadja N Janzen Constantin C Lou Jianlong J Marks James D JD Binz Thomas T Rummel Andreas A
FEBS letters 20140225 7
Botulinum neurotoxins (BoNTs) inhibit neurotransmitter release by hydrolysing SNARE proteins. The most important serotype BoNT/A employs the synaptic vesicle glycoprotein 2 (SV2) isoforms A-C as neuronal receptors. Here, we identified their binding site by blocking SV2 interaction using monoclonal antibodies with characterised epitopes within the cell binding domain (HC). The site is located on the backside of the conserved ganglioside binding pocket at the interface of the HCC and HCN subdomain ...[more]