Ontology highlight
ABSTRACT:
SUBMITTER: Castillo HA
PROVIDER: S-EPMC4074295 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Development (Cambridge, England) 20100201 3
Comparative studies of the tetrapod raldh2 (aldh1a2) gene, which encodes a retinoic acid (RA) synthesis enzyme, have led to the identification of a dorsal spinal cord enhancer. Enhancer activity is directed dorsally to the roof plate and dorsal-most (dI1) interneurons through predicted Tcf- and Cdx-homeodomain binding sites and is repressed ventrally via predicted Tgif homeobox and ventral Lim-homeodomain binding sites. Raldh2 and Math1/Cath1 expression in mouse and chicken highlights a novel, t ...[more]