Ontology highlight
ABSTRACT:
SUBMITTER: Byun H
PROVIDER: S-EPMC4080680 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Byun Hyewon H Gou Yongqiang Y Zook Adam A Lozano Mary M MM Dudley Jaquelin P JP
Frontiers in microbiology 20140703
Endoplasmic reticulum (ER)-associated degradation (ERAD) is a universally important process among eukaryotic cells. ERAD is necessary to preserve cell integrity since the accumulation of defective proteins results in diseases associated with neurological dysfunction, cancer, and infections. This process involves recognition of misfolded or misassembled proteins that have been translated in association with ER membranes. Recognition of ERAD substrates leads to their extraction through the ER memb ...[more]