Ontology highlight
ABSTRACT:
SUBMITTER: DeSieno MA
PROVIDER: S-EPMC4091617 | biostudies-literature | 2011 Sep
REPOSITORIES: biostudies-literature
Chemical communications (Cambridge, England) 20110810 36
The Fe(II) and α-ketoglutarate-dependent hydroxylase FrbJ was previously demonstrated to utilize FR-900098 synthesizing a second phosphonate FR-33289. Here we assessed its ability to hydroxylate other possible substrates, generating a library of potential antimalarial compounds. Through a series of bioassays and in vitro experiments, we identified two new antimalarials. ...[more]