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Characterization and application of the Fe(II) and ?-ketoglutarate dependent hydroxylase FrbJ.

ABSTRACT: The Fe(II) and ?-ketoglutarate-dependent hydroxylase FrbJ was previously demonstrated to utilize FR-900098 synthesizing a second phosphonate FR-33289. Here we assessed its ability to hydroxylate other possible substrates, generating a library of potential antimalarial compounds. Through a series of bioassays and in vitro experiments, we identified two new antimalarials.

SUBMITTER: DeSieno MA 

PROVIDER: S-EPMC4091617 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature

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Characterization and application of the Fe(II) and α-ketoglutarate dependent hydroxylase FrbJ.

DeSieno Matthew A MA   van der Donk Wilfred A WA   Zhao Huimin H  

Chemical communications (Cambridge, England) 20110810 36

The Fe(II) and α-ketoglutarate-dependent hydroxylase FrbJ was previously demonstrated to utilize FR-900098 synthesizing a second phosphonate FR-33289. Here we assessed its ability to hydroxylate other possible substrates, generating a library of potential antimalarial compounds. Through a series of bioassays and in vitro experiments, we identified two new antimalarials. ...[more]

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