Ontology highlight
ABSTRACT:
SUBMITTER: Bertalan Z
PROVIDER: S-EPMC4104050 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Bertalan Zsolt Z La Porta Caterina A M CAM Maiato Helder H Zapperi Stefano S
Biophysical journal 20140701 2
Regulating the stability of microtubule (MT)-kinetochore attachments is fundamental to avoiding mitotic errors and ensuring proper chromosome segregation during cell division. Although biochemical factors involved in this process have been identified, their mechanics still need to be better understood. Here we introduce and simulate a mechanical model of MT-kinetochore interactions in which the stability of the attachment is ruled by the geometrical conformations of curling MT-protofilaments ent ...[more]