Ontology highlight
ABSTRACT:
SUBMITTER: Sherwood TC
PROVIDER: S-EPMC4105056 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Journal of the American Chemical Society 20140624 27
Although dimeric natural products can often be synthesized in the laboratory by directly merging advanced monomers, these approaches sometimes fail, leading instead to non-natural architectures via incorrect unions. Such a situation arose during our studies of the coccinellid alkaloids, when attempts to directly dimerize Nature's presumed monomeric precursors in a putative biomimetic sequence afforded only a non-natural analogue through improper regiocontrol. Herein, we outline a unique strategy ...[more]