Ontology highlight
ABSTRACT:
SUBMITTER: Park S
PROVIDER: S-EPMC4125106 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Park Sangbin S Alfa Ronald W RW Topper Sydni M SM Kim Grace E S GE Kockel Lutz L Kim Seung K SK
PLoS genetics 20140807 8
Insulin is a major regulator of metabolism in metazoans, including the fruit fly Drosophila melanogaster. Genome-wide association studies (GWAS) suggest a genetic basis for reductions of both insulin sensitivity and insulin secretion, phenotypes commonly observed in humans with type 2 diabetes mellitus (T2DM). To identify molecular functions of genes linked to T2DM risk, we developed a genetic tool to measure insulin-like peptide 2 (Ilp2) levels in Drosophila, a model organism with superb experi ...[more]