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In vitro activities of eight antifungal drugs against 104 environmental and clinical isolates of Aureobasidium pullulans.

ABSTRACT: Aureobasidium pullulans is an unusual agent of phaeohyphomycosis. The in vitro activities of antifungals against 104 isolates of Aureobasidium pullulans var. pullulans and A. pullulans var. melanigenum revealed low MIC90s of amphotericin B, posaconazole, and itraconazole. However, they were resistant to fluconazole (?64 ?g/ml) and had high MICs of voriconazole, isavuconazole, caspofungin, and micafungin.

SUBMITTER: Najafzadeh MJ

PROVIDER: S-EPMC4135826 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature

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In vitro activities of eight antifungal drugs against 104 environmental and clinical isolates of Aureobasidium pullulans.

Najafzadeh M Javad MJ Sutton Deanna A DA Keisari M Saradeghi MS Zarrinfar H H de Hoog G Sybren GS Chowdhary Anuradha A Meis Jacques F JF

Antimicrobial agents and chemotherapy 20140707 9

Aureobasidium pullulans is an unusual agent of phaeohyphomycosis. The in vitro activities of antifungals against 104 isolates of Aureobasidium pullulans var. pullulans and A. pullulans var. melanigenum revealed low MIC90s of amphotericin B, posaconazole, and itraconazole. However, they were resistant to fluconazole (≥64 μg/ml) and had high MICs of voriconazole, isavuconazole, caspofungin, and micafungin. ...[more]

PMID: 25001309

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