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In vitro activities of eight antifungal drugs against 106 waterborne and cutaneous exophiala species.

ABSTRACT: The in vitro activities of eight antifungal drugs against 106 clinical and environmental isolates of waterborne and cutaneous Exophiala species were tested. The MICs and minimum effective concentrations for 90% of the strains tested (n = 106) were, in increasing order, as follows: posaconazole, 0.063 ?g/ml; itraconazole, 0.25 ?g/ml; micafungin, 1 ?g/ml; voriconazole, 2 ?g/ml; isavuconazole, 4 ?g/ml; caspofungin, 8 ?g/ml; amphotericin B, 16 ?g/ml; fluconazole, 64 ?g/ml.

SUBMITTER: Najafzadeh MJ

PROVIDER: S-EPMC3837864 | biostudies-other | 2013 Dec

REPOSITORIES: biostudies-other

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In vitro activities of eight antifungal drugs against 106 waterborne and cutaneous exophiala species.

Najafzadeh M J MJ Saradeghi Keisari M M Vicente V A VA Feng P P Shamsian S A A SA Rezaei-Matehkolaei A A de Hoog G S GS Curfs-Breuker I I Meis J F JF

Antimicrobial agents and chemotherapy 20131007 12

The in vitro activities of eight antifungal drugs against 106 clinical and environmental isolates of waterborne and cutaneous Exophiala species were tested. The MICs and minimum effective concentrations for 90% of the strains tested (n = 106) were, in increasing order, as follows: posaconazole, 0.063 μg/ml; itraconazole, 0.25 μg/ml; micafungin, 1 μg/ml; voriconazole, 2 μg/ml; isavuconazole, 4 μg/ml; caspofungin, 8 μg/ml; amphotericin B, 16 μg/ml; fluconazole, 64 μg/ml. ...[more]

PMID: 24100491

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