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In Vitro Activities of Eight Antifungal Drugs against a Global Collection of Genotyped Exserohilum Isolates.

ABSTRACT: The in vitro susceptibilities of 24 worldwide Exserohilum isolates belonging to 10 species from human and environmental sources were determined for eight antifungal drugs. The strains were characterized by internal transcribed spacer (ITS) sequencing and amplified fragment length polymorphism fingerprinting. Posaconazole had the lowest geometric mean MIC (0.16 ?g/ml), followed by micafungin (0.21 ?g/ml), amphotericin B (0.24 ?g/ml), itraconazole (0.33 ?g/ml), voriconazole (0.8 ?g/ml), caspofungin (1.05 ?g/ml), isavuconazole (1.38 ?g/ml), and fluconazole (15.6 ?g/ml).

SUBMITTER: Chowdhary A

PROVIDER: S-EPMC4576068 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature

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In Vitro Activities of Eight Antifungal Drugs against a Global Collection of Genotyped Exserohilum Isolates.

Chowdhary Anuradha A Hagen Ferry F Curfs-Breuker Ilse I Madrid Hugo H de Hoog G Sybren GS Meis Jacques F JF

Antimicrobial agents and chemotherapy 20150803 10

The in vitro susceptibilities of 24 worldwide Exserohilum isolates belonging to 10 species from human and environmental sources were determined for eight antifungal drugs. The strains were characterized by internal transcribed spacer (ITS) sequencing and amplified fragment length polymorphism fingerprinting. Posaconazole had the lowest geometric mean MIC (0.16 μg/ml), followed by micafungin (0.21 μg/ml), amphotericin B (0.24 μg/ml), itraconazole (0.33 μg/ml), voriconazole (0.8 μg/ml), caspofungi ...[more]

PMID: 26239995

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