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A mild, catalyst-free synthesis of 2-aminopyridines.

ABSTRACT: Alkylation of 2-mercaptopyridine with 1,2-dibromoethane affords a cyclic dihydrothiazolopyridinium salt that can serve as a precursor of 2-aminopyridines. Its reaction with primary or secondary amines, either neat or in DMSO, under mild conditions gives the title compounds.

SUBMITTER: Poola B

PROVIDER: S-EPMC4143138 | biostudies-literature | 2008 Nov

REPOSITORIES: biostudies-literature

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A mild, catalyst-free synthesis of 2-aminopyridines.

Poola Bhaskar B Choung Wonken W Nantz Michael H MH

Tetrahedron 20081101 48

Alkylation of 2-mercaptopyridine with 1,2-dibromoethane affords a cyclic dihydrothiazolopyridinium salt that can serve as a precursor of 2-aminopyridines. Its reaction with primary or secondary amines, either neat or in DMSO, under mild conditions gives the title compounds. ...[more]

PMID: 25165405

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