Ontology highlight
ABSTRACT:
SUBMITTER: Samarasinghe RA
PROVIDER: S-EPMC4152385 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Samarasinghe Ranmal A RA Kanuparthi Prasad S PS Timothy Greenamyre J J DeFranco Donald B DB Di Maio Roberto R
Neurobiology of disease 20140706
While aberrant cell proliferation and differentiation may contribute to epileptogenesis, the mechanisms linking an initial epileptic insult to subsequent changes in cell fate remain elusive. Using both mouse and human iPSC-derived neural progenitor/stem cells (NPSCs), we found that a combined transient muscarinic and mGluR1 stimulation inhibited overall neurogenesis but enhanced NPSC differentiation into immature GABAergic cells. If treated NPSCs were further passaged, they retained a nearly ide ...[more]