Ontology highlight
ABSTRACT:
SUBMITTER: Colquitt BM
PROVIDER: S-EPMC4153871 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Colquitt Bradley M BM Markenscoff-Papadimitriou Eirene E Duffié Rachel R Lomvardas Stavros S
Neuron 20140807 4
During differentiation, neurons exhibit a reorganization of DNA modification patterns across their genomes. The de novo DNA methyltransferase Dnmt3a is implicated in this process, but the effects of its absence have not been fully characterized in a purified neuronal population. To better understand how DNA modifications contribute to neuronal function, we performed a comprehensive analysis of the epigenetic and transcriptional landscapes of Dnmt3a-deficient mature olfactory sensory neurons (mOS ...[more]