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Particle replication in nonwetting templates nanoparticles with tumor selective alkyl silyl ether docetaxel prodrug reduces toxicity.

ABSTRACT: Delivery systems designed to have triggered release after passively targeting the tumor may improve small molecule chemotherapeutic delivery. Particle replication in nonwetting templates was used to prepare nanoparticles to passively target solid tumors in an A549 subcutaneous xenograft model. An acid labile prodrug was delivered to minimize systemic free docetaxel concentrations and improve tolerability without compromising efficacy.

SUBMITTER: Chu KS

PROVIDER: S-EPMC4157645 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature

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Particle replication in nonwetting templates nanoparticles with tumor selective alkyl silyl ether docetaxel prodrug reduces toxicity.

Chu Kevin S KS Finniss Mathew C MC Schorzman Allison N AN Kuijer Jennifer L JL Luft J Christopher JC Bowerman Charles J CJ Napier Mary E ME Haroon Zishan A ZA Zamboni William C WC DeSimone Joseph M JM

Nano letters 20140224 3

Delivery systems designed to have triggered release after passively targeting the tumor may improve small molecule chemotherapeutic delivery. Particle replication in nonwetting templates was used to prepare nanoparticles to passively target solid tumors in an A549 subcutaneous xenograft model. An acid labile prodrug was delivered to minimize systemic free docetaxel concentrations and improve tolerability without compromising efficacy. ...[more]

PMID: 24552251

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