Ontology highlight
ABSTRACT:
SUBMITTER: Aguirre Hernandez G
PROVIDER: S-EPMC4158516 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Acta crystallographica. Section E, Structure reports online 20140723 Pt 8
The title compound, C21H24N4O2, is a potent serotonin 5-HT2 and α1-adrenoceptor antagonist. The n-propyl chain links the quinazolinedione heterocycle and the phenyl-piperazine group in which the benzene ring is equatorially located and the piperazine ring has the expected chair conformation. The dihedral angle between the planes of the benzene ring and the quinazolinedione ring system is 74.1 (1)°. In the crystal, mol-ecules form centrosymmetric dimers through R 2 (2)(8) hydrogen-bonded rings in ...[more]