Ontology highlight
ABSTRACT:
SUBMITTER: Romagnoli R
PROVIDER: S-EPMC4159078 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Journal of medicinal chemistry 20140728 15
A new class of compounds that incorporated the structural motif of the 1-(3',4',5'-trimethoxtbenzoyl)-3-arylamino-5-amino-1,2,4-triazole molecular skeleton was synthesized and evaluated for their antiproliferative activity in vitro, interactions with tubulin, and cell cycle effects. The most active agent, 3c, was evaluated for antitumor activity in vivo. Structure-activity relationships were elucidated with various substituents on the phenyl ring of the anilino moiety at the C-3 position of the ...[more]