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Asymmetric gold-catalyzed lactonizations in water at room temperature.

ABSTRACT: Asymmetric gold-catalyzed hydrocarboxylations are reported that show broad substrate scope. The hydrophobic effect associated with in?situ-formed aqueous nanomicelles gives good to excellent ee's of product lactones. In-flask product isolation, along with the recycling of the catalyst and the reaction medium, are combined to arrive at an especially environmentally friendly process.

SUBMITTER: Handa S

PROVIDER: S-EPMC4193796 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature

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Asymmetric gold-catalyzed lactonizations in water at room temperature.

Handa Sachin S Lippincott Daniel J DJ Aue Donald H DH Lipshutz Bruce H BH

Angewandte Chemie (International ed. in English) 20140814 40

Asymmetric gold-catalyzed hydrocarboxylations are reported that show broad substrate scope. The hydrophobic effect associated with in situ-formed aqueous nanomicelles gives good to excellent ee's of product lactones. In-flask product isolation, along with the recycling of the catalyst and the reaction medium, are combined to arrive at an especially environmentally friendly process. ...[more]

PMID: 25124085

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