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Micellar catalysis-enabled sustainable ppm Au-catalyzed reactions in water at room temperature.

ABSTRACT: Several ppm level gold-catalyzed reactions enabled by the ligand HandaPhos can be performed at room temperature in aqueous nanoreactors composed of the surfactant Nok. Variously substituted allenes undergo cycloisomerization leading to heterocyclic products in good yields. Likewise, cyclodehydration is also illustrated under similar conditions, as is an intermolecular variant, hydration of terminal alkynes. Recycling of the catalyst and reaction medium is also illustrated. A low E factor associated with limited solvent use and therefore, waste generation, documents the greenness of this process.

SUBMITTER: Klumphu P

PROVIDER: S-EPMC5628599 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature

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Micellar catalysis-enabled sustainable ppm Au-catalyzed reactions in water at room temperature.

Klumphu Piyatida P Desfeux Camille C Zhang Yitao Y Handa Sachin S Gallou Fabrice F Lipshutz Bruce H BH

Chemical science 20170720 9

Several ppm level gold-catalyzed reactions enabled by the ligand HandaPhos can be performed at room temperature in aqueous nanoreactors composed of the surfactant Nok. Variously substituted allenes undergo cycloisomerization leading to heterocyclic products in good yields. Likewise, cyclodehydration is also illustrated under similar conditions, as is an intermolecular variant, hydration of terminal alkynes. Recycling of the catalyst and reaction medium is also illustrated. A low <i>E</i> factor ...[more]

PMID: 28989668

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