Ontology highlight
ABSTRACT:
SUBMITTER: Springelkamp H
PROVIDER: S-EPMC4199103 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Nature communications 20140922
Glaucoma is characterized by irreversible optic nerve degeneration and is the most frequent cause of irreversible blindness worldwide. Here, the International Glaucoma Genetics Consortium conducts a meta-analysis of genome-wide association studies of vertical cup-disc ratio (VCDR), an important disease-related optic nerve parameter. In 21,094 individuals of European ancestry and 6,784 individuals of Asian ancestry, we identify 10 new loci associated with variation in VCDR. In a separate risk-sco ...[more]