Ontology highlight
ABSTRACT:
SUBMITTER: Ingle G
PROVIDER: S-EPMC4227545 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Ingle Gajendrasingh G Mormino Michael G MG Antilla Jon C JC
Organic letters 20141015 21
A highly enantioselective method for desymmetrization of meso-epoxides using thiols is reported. This is the first example of epoxide activation achieved using metal BINOL phosphates. The reaction has a broad scope in terms of epoxide substrates and aromatic thiol nucleophiles. The resulting β-hydroxyl sulfides are obtained in excellent yield and enantioselectivity. ...[more]