Ontology highlight
ABSTRACT:
SUBMITTER: Fukuda A
PROVIDER: S-EPMC4243243 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Nature communications 20141114
Maintaining a single active X-chromosome by repressing Xist is crucial for embryonic development in mice. Although the Xist activator RNF12/RLIM is present as a maternal factor, maternal Xist (Xm-Xist) is repressed during preimplantation phases to establish imprinted X-chromosome inactivation (XCI). Here we show, using a highly reproducible chromatin immunoprecipitation method that facilitates chromatin analysis of preimplantation embryos, that H3K9me3 is enriched at the Xist promoter region, pr ...[more]