Ontology highlight
ABSTRACT:
SUBMITTER: Diaz-Saez L
PROVIDER: S-EPMC4243253 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Díaz-Sáez Laura L Srikannathasan Velupillai V Zoltner Martin M Hunter William N WN
The Biochemical journal 20140901 3
Tryptophan is an important precursor for chemical entities that ultimately support the biosynthesis of key metabolites. The second stage of tryptophan catabolism is catalysed by kynurenine formamidase, an enzyme that is different between eukaryotes and prokaryotes. In the present study, we characterize the catalytic properties and present the crystal structures of three bacterial kynurenine formamidases. The structures reveal a new amidase protein fold, a highly organized and distinctive binucle ...[more]