Ontology highlight
ABSTRACT:
SUBMITTER: He R
PROVIDER: S-EPMC4259018 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
MedChemComm 20141001 10
<i>Mycobacterium</i> protein tyrosine phosphatase B (mPTPB) is a potential drug target of Tuberculosis (TB). Small molecule inhibitors of mPTPB could be a treatment to overcome emerging TB drug resistance. Using a Diversity-Oriented Synthesis (DOS) strategy, we successfully developed a salicylic acid based and drug-like mPTPB inhibitor with an IC<sub>50</sub> of 2 μM and >20-fold specificity over many human PTPs, making it an excellent lead molecule for anti-TB drug discovery. In addition, DOS g ...[more]