Ontology highlight
ABSTRACT:
SUBMITTER: Einarsdottir BO
PROVIDER: S-EPMC4259423 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Einarsdottir Berglind O BO Bagge Roger Olofsson RO Bhadury Joydeep J Jespersen Henrik H Mattsson Jan J Nilsson Lisa M LM Truvé Katarina K López Marcela Dávila MD Naredi Peter P Nilsson Ola O Stierner Ulrika U Ny Lars L Nilsson Jonas A JA
Oncotarget 20141001 20
The development of novel therapies against melanoma would benefit from individualized tumor models to ensure the rapid and accurate identification of biomarkers of therapy response. Previous studies have suggested that patient-derived xenografts (PDXes) could be useful. However, the utility of PDXes in guiding real-time treatment decisions has only been reported in anecdotal forms. Here tumor biopsies from patients with stage III and IV metastatic malignant melanoma were transplanted into immuno ...[more]