Rapidly-dissolvable microneedle patches via a highly scalable and reproducible soft lithography approach.
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ABSTRACT:
SUBMITTER: Moga KA
PROVIDER: S-EPMC4262250 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
Publications
Rapidly-dissolvable microneedle patches via a highly scalable and reproducible soft lithography approach.
Moga Katherine A KA Bickford Lissett R LR Geil Robert D RD Dunn Stuart S SS Pandya Ashish A AA Wang Yapei Y Fain John H JH Archuleta Christine F CF O'Neill Adrian T AT Desimone Joseph M JM
Advanced materials (Deerfield Beach, Fla.) 20130729 36
Microneedle devices for transdermal drug delivery have recently become an attractive method to overcome the diffusion-limiting epidermis and effectively transport therapeutics to the body. Here, we demonstrate the fabrication of highly reproducible and completely dissolvable polymer microneedles on flexible water-soluble substrates. These biocompatible microneedles (made by using a soft lithography process known as PRINT) showed efficacy in piercing both murine and human skin samples and deliver ...[more]
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