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A genome-wide association study of Hodgkin's lymphoma identifies new susceptibility loci at 2p16.1 (REL), 8q24.21 and 10p14 (GATA3).

ABSTRACT: To identify susceptibility loci for classical Hodgkin's lymphoma (cHL), we conducted a genome-wide association study of 589 individuals with cHL (cases) and 5,199 controls with validation in four independent samples totaling 2,057 cases and 3,416 controls. We identified three new susceptibility loci at 2p16.1 (rs1432295, REL, odds ratio (OR) = 1.22, combined P = 1.91 × 10(-8)), 8q24.21 (rs2019960, PVT1, OR = 1.33, combined P = 1.26 × 10(-13)) and 10p14 (rs501764, GATA3, OR = 1.25, combined P = 7.05 × 10(-8)). Furthermore, we confirmed the role of the major histocompatibility complex in disease etiology by revealing a strong human leukocyte antigen (HLA) association (rs6903608, OR = 1.70, combined P = 2.84 × 10(-50)). These data provide new insight into the pathogenesis of cHL.

SUBMITTER: Enciso-Mora V 

PROVIDER: S-EPMC4268499 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature

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A genome-wide association study of Hodgkin's lymphoma identifies new susceptibility loci at 2p16.1 (REL), 8q24.21 and 10p14 (GATA3).

Enciso-Mora Victor V   Broderick Peter P   Ma Yussanne Y   Jarrett Ruth F RF   Hjalgrim Henrik H   Hemminki Kari K   van den Berg Anke A   Olver Bianca B   Lloyd Amy A   Dobbins Sara E SE   Lightfoot Tracy T   van Leeuwen Flora E FE   Försti Asta A   Diepstra Arjan A   Broeks Annegien A   Vijayakrishnan Jayaram J   Shield Lesley L   Lake Annette A   Montgomery Dorothy D   Roman Eve E   Engert Andreas A   von Strandmann Elke Pogge EP   Reiners Katrin S KS   Nolte Ilja M IM   Smedby Karin E KE   Adami Hans-Olov HO   Russell Nicola S NS   Glimelius Bengt B   Hamilton-Dutoit Stephen S   de Bruin Marieke M   Ryder Lars P LP   Molin Daniel D   Sorensen Karina Meden KM   Chang Ellen T ET   Taylor Malcolm M   Cooke Rosie R   Hofstra Robert R   Westers Helga H   van Wezel Tom T   van Eijk Ronald R   Ashworth Alan A   Rostgaard Klaus K   Melbye Mads M   Swerdlow Anthony J AJ   Houlston Richard S RS  

Nature genetics 20101031 12

To identify susceptibility loci for classical Hodgkin's lymphoma (cHL), we conducted a genome-wide association study of 589 individuals with cHL (cases) and 5,199 controls with validation in four independent samples totaling 2,057 cases and 3,416 controls. We identified three new susceptibility loci at 2p16.1 (rs1432295, REL, odds ratio (OR) = 1.22, combined P = 1.91 × 10(-8)), 8q24.21 (rs2019960, PVT1, OR = 1.33, combined P = 1.26 × 10(-13)) and 10p14 (rs501764, GATA3, OR = 1.25, combined P = 7  ...[more]

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