Genetic association analysis and meta-analysis of imputed SNPs in longitudinal studies.
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ABSTRACT:
SUBMITTER: Subirana I
PROVIDER: S-EPMC4273087 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
Publications
Genetic association analysis and meta-analysis of imputed SNPs in longitudinal studies.
Subirana Isaac I González Juan R JR
Genetic epidemiology 20130417 5
In this paper we propose a new method to analyze time-to-event data in longitudinal genetic studies. This method address the fundamental problem of incorporating uncertainty when analyzing survival data and imputed single-nucleotide polymorphisms (SNPs) from genome-wide association studies (GWAS). Our method incorporates uncertainty in the likelihood function, the opposite of existing methods that incorporate the uncertainty in the design matrix. Through simulation studies and real data analyses ...[more]
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