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Emerging regulation and function of betatrophin.

ABSTRACT: Betatrophin, also known as TD26/RIFL/lipasin/ANGPTL8/C19orf80, is a novel protein predominantly expressed in human liver. To date, several betatrophin orthologs have been identified in mammals. Increasing evidence has revealed an association between betatrophin expression and serum lipid profiles, particularly in patients with obesity or diabetes. Stimulators of betatrophin, such as insulin, thyroid hormone, irisin and caloric intake, are usually relevant to energy expenditure or thermogenesis. In murine models, serum triglyceride levels as well as pancreatic cell proliferation are potently enhanced by betatrophin. Intriguingly, conflicting phenomena have also been reported that betatrophin suppresses hepatic triglyceride levels, suggesting that betatrophin function is mediated by complex regulatory processes. However, its precise physiological role remains unclear at present. In this review, we have summarized the current findings on betatrophin and their implications.

SUBMITTER: Tseng YH

PROVIDER: S-EPMC4284785 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature

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Emerging regulation and function of betatrophin.

Tseng Yi-Hsin YH Yeh Yung-Hsin YH Chen Wei-Jan WJ Lin Kwang-Huei KH

International journal of molecular sciences 20141218 12

Betatrophin, also known as TD26/RIFL/lipasin/ANGPTL8/C19orf80, is a novel protein predominantly expressed in human liver. To date, several betatrophin orthologs have been identified in mammals. Increasing evidence has revealed an association between betatrophin expression and serum lipid profiles, particularly in patients with obesity or diabetes. Stimulators of betatrophin, such as insulin, thyroid hormone, irisin and caloric intake, are usually relevant to energy expenditure or thermogenesis. ...[more]

PMID: 25530616

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Betatrophin.

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ANGPTL8/betatrophin does not control pancreatic beta cell expansion.

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Betatrophin: a hormone that controls pancreatic β cell proliferation.

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