Ontology highlight
ABSTRACT:
SUBMITTER: Barford D
PROVIDER: S-EPMC4308986 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Philosophical transactions. Series A, Mathematical, physical, and engineering sciences 20150301 2036
The process of chromosome division, termed mitosis, involves a complex sequence of events that is tightly controlled to ensure that the faithful segregation of duplicated chromosomes is coordinated with each cell division cycle. The large macromolecular complex responsible for regulating this process is the anaphase-promoting complex or cyclosome (APC/C). In humans, the APC/C is assembled from 20 subunits derived from 15 different proteins. The APC/C functions to ubiquitinate cell cycle regulato ...[more]