Ontology highlight
ABSTRACT:
SUBMITTER: Laky K
PROVIDER: S-EPMC4314725 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Laky Karen K Evans Sharron S Perez-Diez Ainhoa A Fowlkes B J BJ
Immunity 20150101 1
Adaptive immune responses begin when naive CD4(+) T cells engage peptide+major histocompatibility complex class II and co-stimulatory molecules on antigen-presenting cells (APCs). Notch signaling can influence effector functions in differentiated CD4(+) T helper and T regulatory cells. Whether and how ligand-induced Notch signaling influences the initial priming of CD4(+) T cells has not been addressed. We have found that Delta Like Ligand 4 (DLL4)-induced Notch signaling potentiates phosphatidy ...[more]