Ontology highlight
ABSTRACT:
SUBMITTER: Mateo JL
PROVIDER: S-EPMC4317172 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Mateo Juan L JL van den Berg Debbie L C DL Haeussler Maximilian M Drechsel Daniela D Gaber Zachary B ZB Castro Diogo S DS Robson Paul P Lu Q Richard QR Crawford Gregory E GE Flicek Paul P Ettwiller Laurence L Wittbrodt Joachim J Guillemot François F Martynoga Ben B
Genome research 20141007 1
The gene regulatory network (GRN) that supports neural stem cell (NS cell) self-renewal has so far been poorly characterized. Knowledge of the central transcription factors (TFs), the noncoding gene regulatory regions that they bind to, and the genes whose expression they modulate will be crucial in unlocking the full therapeutic potential of these cells. Here, we use DNase-seq in combination with analysis of histone modifications to identify multiple classes of epigenetically and functionally d ...[more]