Bone fracture toughness and strength correlate with collagen cross-link maturity in a dose-controlled lathyrism mouse model.
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ABSTRACT:
SUBMITTER: McNerny EM
PROVIDER: S-EPMC4333018 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
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Bone fracture toughness and strength correlate with collagen cross-link maturity in a dose-controlled lathyrism mouse model.
McNerny Erin M B EM Gong Bo B Morris Michael D MD Kohn David H DH
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20150301 3
Collagen cross-linking is altered in many diseases of bone, and enzymatic collagen cross-links are important to bone quality, as evidenced by losses of strength after lysyl oxidase inhibition (lathyrism). We hypothesized that cross-links also contribute directly to bone fracture toughness. A mouse model of lathyrism using subcutaneous injection of up to 500 mg/kg β-aminopropionitrile (BAPN) was developed and characterized (60 animals across 4 dosage groups). Three weeks of 150 or 350 mg/kg BAPN ...[more]
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