Ontology highlight
ABSTRACT:
SUBMITTER: Richers MT
PROVIDER: S-EPMC4333595 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Journal of the American Chemical Society 20140414 16
Cyclic secondary amines and 2-hydroxybenzaldehydes or related ketones react to furnish benzo[e][1,3]oxazine structures in generally good yields. This overall redox-neutral amine α-C-H functionalization features a combined reductive N-alkylation/oxidative α-functionalization and is catalyzed by acetic acid. In contrast to previous reports, no external oxidants or metal catalysts are required. Reactions performed under modified conditions lead to an apparent reductive amination and the formation o ...[more]