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New reactions of 2-methylenetetrahydropyrans. A three component coupling protocol for the synthesis of tetrahydropyranyl ketides.

ABSTRACT: Three component coupling of a 2-methylenetetrahydropyran, an activated aldehyde or ketone and a secondary nucleophile provides an efficient preparation of tetrahydropyranyl ketides, a unit common to many complex natural products.

SUBMITTER: Liang G

PROVIDER: S-EPMC4335680 | biostudies-literature | 2009 Nov

REPOSITORIES: biostudies-literature

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New reactions of 2-methylenetetrahydropyrans. A three component coupling protocol for the synthesis of tetrahydropyranyl ketides.

Liang Guohua G Bateman Laura J LJ Totah Nancy I NI

Chemical communications (Cambridge, England) 20090923 42

Three component coupling of a 2-methylenetetrahydropyran, an activated aldehyde or ketone and a secondary nucleophile provides an efficient preparation of tetrahydropyranyl ketides, a unit common to many complex natural products. ...[more]

PMID: 19841808

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