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Mild, Pd-catalyzed stannylation of radioiodination targets.

ABSTRACT: Trialkylstannanes are versatile precursors for chemical transformations, including radiolabeling with a variety of halogens, particularly iodine. In the present work a convenient, Pd-mediated stannylation method is presented that can be performed in an open flask. The method is selective for aryl iodides allowing selective stannylations in the presence of other halogen atoms. The reaction conditions are mild, making the method compatible with chemically sensitive bioactive compounds.

SUBMITTER: Pickett JE

PROVIDER: S-EPMC4385467 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature

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Mild, Pd-catalyzed stannylation of radioiodination targets.

Pickett Julie E JE Váradi András A Palmer Travis C TC Grinnell Steven G SG Schrock Joel M JM Pasternak Gavril W GW Karimov Rashad R RR Majumdar Susruta S

Bioorganic & medicinal chemistry letters 20150302 8

Trialkylstannanes are versatile precursors for chemical transformations, including radiolabeling with a variety of halogens, particularly iodine. In the present work a convenient, Pd-mediated stannylation method is presented that can be performed in an open flask. The method is selective for aryl iodides allowing selective stannylations in the presence of other halogen atoms. The reaction conditions are mild, making the method compatible with chemically sensitive bioactive compounds. ...[more]

PMID: 25777268

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