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Light sensitization of DNA nanostructures via incorporation of photo-cleavable spacers.

ABSTRACT: Using light irradiation as a trigger, large-scale structural reconfiguration of DNA nanostructures is demonstrated. We incorporated photo-cleavable spacers at strategic locations within the short oligonucleotide strands connecting adjacent helices within a DNA origami sphere, and then used light to transform the sphere into two tethered hemispheres.

SUBMITTER: Kohman RE

PROVIDER: S-EPMC4394657 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature

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Light sensitization of DNA nanostructures via incorporation of photo-cleavable spacers.

Kohman Richie E RE Han Xue X

Chemical communications (Cambridge, England) 20150401 26

Using light irradiation as a trigger, large-scale structural reconfiguration of DNA nanostructures is demonstrated. We incorporated photo-cleavable spacers at strategic locations within the short oligonucleotide strands connecting adjacent helices within a DNA origami sphere, and then used light to transform the sphere into two tethered hemispheres. ...[more]

PMID: 25720373

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