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The role of the ubiquitin-editing enzyme A20 in diseases of the central nervous system and other pathological processes.

ABSTRACT: In recent years, the ubiquitin-editing enzyme A20 has been shown to control a large set of molecular pathways involved in the regulation of protective as well as self-directed immune responses. Here, we assess the current and putative roles of A20 in inflammatory, vascular and degenerative diseases of the central nervous system and explore future directions of research.

SUBMITTER: Abbasi A 

PROVIDER: S-EPMC4466442 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature

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The role of the ubiquitin-editing enzyme A20 in diseases of the central nervous system and other pathological processes.

Abbasi Asghar A   Forsberg Kirsi K   Bischof Felix F  

Frontiers in molecular neuroscience 20150615

In recent years, the ubiquitin-editing enzyme A20 has been shown to control a large set of molecular pathways involved in the regulation of protective as well as self-directed immune responses. Here, we assess the current and putative roles of A20 in inflammatory, vascular and degenerative diseases of the central nervous system and explore future directions of research. ...[more]

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