Ontology highlight
ABSTRACT:
SUBMITTER: Vetters J
PROVIDER: S-EPMC6719426 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
The Journal of experimental medicine 20190711 9
The ubiquitin-editing enzyme A20 is a well-known regulator of immune cell function and homeostasis. In addition, A20 protects cells from death in an ill-defined manner. While most studies focus on its role in the TNF-receptor complex, we here identify a novel component in the A20-mediated decision between life and death. Loss of A20 in NK cells led to spontaneous NK cell death and severe NK cell lymphopenia. The few remaining NK cells showed an immature, hyperactivated phenotype, hallmarked by t ...[more]