Ontology highlight
ABSTRACT:
SUBMITTER: Shembade N
PROVIDER: S-EPMC2657574 | biostudies-other | 2009 Mar
REPOSITORIES: biostudies-other
Shembade Noula N Parvatiyar Kislay K Harhaj Nicole S NS Harhaj Edward W EW
The EMBO journal 20090108 5
The RING domain protein RNF11 is overexpressed in breast cancers and promotes tumour growth factor-beta (TGF-beta) signalling. RNF11 has been proposed to regulate TGF-beta signalling by interacting with HECT- and SCF-type E3 ligases; however, the role of RNF11 in other signalling pathways is poorly understood. Here, we demonstrate a novel function of RNF11 as a negative regulator of NF-kappaB and jun N-terminal kinase (JNK) signalling pathways. Knockdown of RNF11 with siRNA resulted in persisten ...[more]