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CD93 gene polymorphism is associated with disseminated colorectal cancer.

ABSTRACT: Cluster of differentiation 93 (CD93) is involved in apoptosis and inflammation and has a suggested role in angiogenesis, and all of which are involved in the development and dissemination of cancer. We evaluated the expression of CD93 and the association with two single nucleotide polymorphisms (SNPs), rs2749812 and rs2749817, as possible biomarkers in colorectal cancer (CRC).Tissue levels and plasma levels of CD93 were measured using an enzyme-linked immunosorbent assay (ELISA). Expression of CD93 was determined by immunohistochemistry, western blot and gene expression analysis. Genotype frequencies were established for the SNPs by real-time polymerase chain reaction (PCR), and the association with tumour stage and survival was analysed.Total CD93 levels were 82% higher (P?

SUBMITTER: Olsen RS

PROVIDER: S-EPMC4471320 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature

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CD93 gene polymorphism is associated with disseminated colorectal cancer.

Olsen Renate S RS Lindh Mikael M Vorkapic Emina E Andersson Roland E RE Zar Niklas N Löfgren Sture S Dimberg Jan J Matussek Andreas A Wågsäter Dick D

International journal of colorectal disease 20150526 7

<h4>Purpose</h4>Cluster of differentiation 93 (CD93) is involved in apoptosis and inflammation and has a suggested role in angiogenesis, and all of which are involved in the development and dissemination of cancer. We evaluated the expression of CD93 and the association with two single nucleotide polymorphisms (SNPs), rs2749812 and rs2749817, as possible biomarkers in colorectal cancer (CRC).<h4>Methods</h4>Tissue levels and plasma levels of CD93 were measured using an enzyme-linked immunosorben ...[more]

PMID: 26008729

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