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Supercharged green fluorescent proteins as bimodal reporter genes for CEST MRI and optical imaging.


ABSTRACT: Superpositively charged mutants of green fluorescent protein (GFP) demonstrated a dramatically improved chemical exchange saturation transfer (CEST) MRI contrast compared to their wild type counterparts. The mutants +36 GFP and +48 GFP were successfully expressed in mammalian cells and retained part of their fluorescence, making them a new potential bimodal reporter gene.

SUBMITTER: Bar-Shir A 

PROVIDER: S-EPMC4485562 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature

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Supercharged green fluorescent proteins as bimodal reporter genes for CEST MRI and optical imaging.

Bar-Shir Amnon A   Liang Yajie Y   Chan Kannie W Y KW   Gilad Assaf A AA   Bulte Jeff W M JW  

Chemical communications (Cambridge, England) 20150301 23


Superpositively charged mutants of green fluorescent protein (GFP) demonstrated a dramatically improved chemical exchange saturation transfer (CEST) MRI contrast compared to their wild type counterparts. The mutants +36 GFP and +48 GFP were successfully expressed in mammalian cells and retained part of their fluorescence, making them a new potential bimodal reporter gene. ...[more]

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