Ontology highlight
ABSTRACT:
SUBMITTER: Adio S
PROVIDER: S-EPMC4490557 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Nature communications 20150615
The coupled translocation of transfer RNA and messenger RNA through the ribosome entails large-scale structural rearrangements, including step-wise movements of the tRNAs. Recent structural work has visualized intermediates of translocation induced by elongation factor G (EF-G) with tRNAs trapped in chimeric states with respect to 30S and 50S ribosomal subunits. The functional role of the chimeric states is not known. Here we follow the formation of translocation intermediates by single-molecule ...[more]